International Leprosy Association -
History of Leprosy

International Leprosy Association -
History of Leprosy

Database

Central Leprosy Training and Research Institute (CLTRI)

Location

Category Hospital/Research Institute
Country India
Address Chengalpattu, Tamil Nadu, India.
Telephone +91 04114 226275
Fax + 91 04114 226064
URL http://cltri.gov.in/

Notes

The records here are in an extremely vulnerable condition and are, as yet, uncatalogued, yet they represent some of the most important records of clinical, research work, and trials conducted into dapsone resistance and collaboration in clinical trials of combined drug regimens to establish WHO MDT. In addition, the records for the children's clinic at Saidapet are here. Unfortunately, there are no records from before the 1950s, of the Lady Willingdon Sanatorium remaining.

Below is a preliminary list of the records:

Some of the files at Central Leprosy Training and Research Institute, Chingleput

Visitor books from 1959 to 2002

Dispensary records

THELEP records

Proposal from Dr Noordeen to the Medical Research Institute Florida for funding (THELEP) 1981-84, includes project description, objectives, rationale, progress reports

THELEP Individual Observation Records

Health Education as an Alternative Strategy for Case Detection

Rural Field Operation – Body Charts (1985)

UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, 9 th Meeting of the THELEP Steering Committee Geneva, 8-10 April 1981

The Foundation for Medical Research11 March 1918, Dr Sansarricq, THELEP Project, “Study of Bacteriological Load and Viability of M Leprae in Human Nerves, containing an interim summary from Dr Antia

Progress Report on “Synthesis of Clofazimine Analogues and their Evaluation for Antimycobacterial and Mutagenic Activity” Principal Investigator: Dr M L Conalty. Ireland. THELEP. Chemotherapy of Leprosy 1975-1980.

Schieffelin Leprosy Research and Training Centre: Karigiri, Neuritis Workshop (List of Participants included) 12-14 March 1980

IMMLEP/THELEP Review, February 1981

Research Strengthening TDR/Leprosy Component – Position Paper

Progress Reports July 1978- October 1980; March 1981

Clinical Trial in Bamako, Marchoux Institute, C A P Ferracci (19 Febuary 1981)

WHO 9 th Meeting of THELEP Steering Committee, 8-10 April 1981

THELEP Address Book of people involved in trial

WHO – Application for Scientific Work Group Collaborative Research Project, THELEP, to determine the incidence of primary dapsone resistance leprosy in Cuba

CLTRI Tirumani Biopsy Reports, including the name and assigned an number from B01-B999; B 1007-B1600

Contact cards for Children at Sidapet

Dr M S Nilakanta Rao, “A Trial on the Use of ‘Fanasil’ (Ro4-4393) in the Treatment of Leprosy”, published October 26 (1965)

SWG: Chempotherapy of Leprosy (THELEP): “Short Term Human Trial of Clofazamine in Previously Untreated Lepromatous Leprosy (BL-LL range) Using Multi-Drug Regimens (Project No 780 315) (1978-1984) (Includes Master Chart with Draft Protocol, Records, Charts)

Clinical and Daily Census File (2 July 1992 – 31 December 1992; 30 June 1992 – 1 July 1992)

Proposal from Drs Ramanujam and Ramu and Swaminathan to demonstrate the R A Factor in leprosy Rheumatoid Arthritis Factor

Correspondence from Dr Ramanijam with suppliers to do with MHQ powder 2-mercapto-3-hydrazino-quinoxalin)

Plan numbering buildings “Proposed Numbers for Buildings in the Institute”

1965 Report of the Leprosy Assessment Sub-Committee, 7 th Meeting

(1 st Meeting 23 November 1961 in Calcutta; 2 nd 23-25 July 1963 in Poona; 3 rd 25 January 1964 in Bhopal; 4 th 20-21 March 1964 in New Delhi)

Records of 1986 Trial of Levamisole

983 Prothionamide Therapy

1986, 1987 WHO Regimen

Mouse Footpad (1 August 1987) (MB sulphone resistant)

Cases of dapsone resistance (1977) and admission and administration of “Lamprene”

1986 RFT cases. Pulse Therapy – Dapsone and Clofazamine and Rifampicin for some

1960s and 70s files DDS treatment and photographs

Rifampicin Trial 1977-78

Drs C G S Iyer and P S Seshadri, “Experiences in the Therapy of Leprosy” (Experiences with Rifampicin in the Treatment of Lepromatous Leprosy)

Drs P S Seshadri and N T Rair “Treatment of Sulphone Resistant Leprosy: A Review of Sixty-One Cases” (draft submitted IAL Cinference, September 1987)

Annual reports from Dr Ramanujam 1971-75, 1972, 1973, 1975 (Clinical Investigations) on dosage of DDS, DDAS, DDS and Thiazetazone

Protocol of Cimetidine Therapy (for peptic ulcers due to drug reactions), files of patient records 1-.5,000 from 1990s onwards

Records on Sulphone Resistance (1970s)

CIM Study

THELEP files (PSS files)

File for Dr Indira Nath 1984 “WHO Lepromatous Leprosy Trial/ Protocol for Seriological Investigation of Rifampicin Toxicity in Previously Untreated Lepromatous Leprosy Patients Receiving Rifampicin” Case record 1985 (1407-4107) (24 January 1985-30 April 1985)

Sidapet Contact Cards 1958

1968 correspondence between Dr Ramanujam and Ray Narain concerning trial BCG with relation to TB “Tuberculosis Prevention Trial” ICMR

Open trial with Thalidomide versus Clofazamine (50 cases) Dartos Muscle Study

Clinical Division: Lepromin Register

Prothionamide Therapy Study (1984-85)

Correspondence with and reports to the Indian Council of Medical Research

Annual Report of the Clinical Division 1962

Monthly returns for the Mobile Unit 1964-1974 (No of Cases, New Cases, Attendance Records)

Folders on Chemoprophylaxis and Immunoprophalaxis with copy of J Kinnear Brown,“BCG Vaccination of Children Against Leprosy: First Result of Trial in Uganda” BMJ No 5478, 1 (1966): 1-58 and WHO Technical Report Series: WHO Expert Committee on TB 8 th Report, No 290

Clinical Division Patients’ Files 1967

File: Correspondence between Bechelli and Iyer on “Combined Treatment DDS-Streptomycin – Isonicotinic Acid Hydrazide” WHO 1967

File: Geigy Lamprene

Brief Note on the Activities of the Investigation Section of the Clinical Division

List: Pulse Regime, THELEP Patients

File: Costicosteroids

File: Immunology Study DNP-HAS (Dinitropheny Human Serum Albumin), including correspondence between Drs Ramu and Ramanujam and David Nelson (Yale) (1966)

File: Study of Alectra Parasitica Rhizone (1963)

File: Tincture of Achyranthes Aspara 7 October 1961

File: Collaborative Work with ENT Surgeon CMC

Trials of Lepsulmin (1963)

Drugs Register

File: Relapse and Annual Report 1971

File on ENL

Correspondence with WHO (Bechelli and C G S Iyer) (1968)

File: Detection of Cases, DDS Study

Open Trial with Clofazimine and Thalidomide in Recurrent Lepra reaction from 20 February 1973 (also with a register for drug supply)

Oflaxacin Study (THELEP) 1989-1992

List of Patients for ETISUL Ointment Group

Folder: Leprosy Association SubCommittee (1964)

Contract Agreement Form from His Excellency the Governor of Madras (Purchaser) with the Contractor (Supplier of Food) for the LWL Sanatorium at Truimani (1953 -)

Entry made November 15, 2005

Contact

Name Dr P K Oommen
Organization Central Leprosy Training and Research Institute (CLTRI, Chingleput)
Address Tirumani (Chingleput), India.
Telephone +91 04114 226275
Fax +91 04114 226064

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