International Leprosy Association -
History of Leprosy

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    History of Leprosy

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    Dr Richard W Truman

    Status Medical Researcher
    Country USA

    Notes

    Dr Richard W Truman is an American immunologist and microbiologist with expertise in leprosy. He received his PhD from Louisiana State University School of Veterinary Medicine in 1985 for his thesis: “Host responses to Mycobacterium leprae”. From 1985 to 1995 he was a research scientist at the Pharmacology Research Department of the National Hansen’s Disease Program at Carville and subsequently, from 1995, became Chief of the Microbiology and Epidemiology Research Department of the National Hansen’s Disease Program at Louisiana State University.

    Dr Truman has shown that leprosy is a zoonotic in the southern US, with there being more than 100,000 infected armadillos in Louisiana and Texas. He established the first M. leprae reference strains and genomic strain markers. He is currently active in leprosy research and maintains a colony of nine-banded armadillos for the propagation of M. leprae in armadillos and translational research studies. He also holds a post as a Regular Corps Officer for the US Public Health Service.

    This entry was created 5 Sept, 2006.

    Research Institute(s) associated with:
    The National Hansen's Disease Programs (NHDP), Baton Rouge, Louisiana, USA

    Publications

    Book Chapters & Other Publications :

    • Truman, RW.“Summary of Hansen’s Disease in the United States - 2005”, NHDP informational brochure, 2006.  
    • Truman, RW.“Leprosy”, in J Loughry (ed), The Xenarthra. University of Florida Press (in press 2006).
    • Brennan, PJ, and Truman, RW. "Report on the NIAID Workshop on Translational Research in Leprosy, Seattle, WA, 2005), Lepr Rev (in press 2006).
    • Scollard, DS, Truman, RW."Armadillos as Models for lepromatous neuropathy", in Deason (ed) Animal Models for Biomedical Research. Academic Press, 1999, pp. 330-336.
    • Truman, RW. (1995) "Environmental Association for M. leprae", in SK Majumdar, EW Miller and FJ Brenner (eds), Environmental Contaminants, Ecosystems and Human Health. 1st edn, Pennsylvania Academy of Sciences, Easton, PA., pp. 437-49.

    Peer Reviewed Publications :

    • Scollard, DM, Adams, LB, Gillis, TP, Krahenbuhl, JL, Truman, RW, and Williams, DL “The Continuing Challenges of Leprosy” Clin Microbiol Rev, 19.2 (2006): 338-381.
    • Adams, JE, Pena, MT, Gillis, TP, Adams, LB, Williams, DL, Truman, RW. “Expression of nine-banded armadillo (Dasypus novemcinctus) interleukin-2 in E. coli ”,Cytokine, 32 (2005): 219-225.
    • Truman, RW. “Leprosy in wild armadillos.” Lepr Rev, 76 (2005): 198-208.
    • Marc Monot, Nadine Honoré, Thierry Garnier, Romulo Araoz, Jean-Yves Coppée, Céline Lacroix, Samba Sow, John Spencer, Richard W TRUMAN, Diana L Williams, Robert Gelber, Marcos Virmond, Béatrice Flageul, Sang-Nae Cho, Baohong Ji, Idani Vasquez, Alberto Paniz Mondolfi, Jacinto Convit, Saroj Young, Voahangy Rasolofo, Patrick J Brennan, and Stewart T Cole. “On the Origin of Leprosy”, Science, 308 (2005): 1040-1042.
    • Williams, DL, Torrero, M, Wheeler, P, Truman, RW, Yoder, M, Morrison, N, Bishai, WR,Gillis, TP. “Biological implications of Mycobacterium leprae gene expression during infection”, J Mol Microb Biotech, 8 (2004): 58-72.
    • Truman, RW, Fontes, AN, Miranda, AB, Suffys, PN, Gillis, TP. ”Genotypic variation and stability of four variable number tandem repeats and the suitability for discriminating strains of Mycobacteriumleprae ”, J Clin Microbiol, 42.6 (2004): 2258-2565.
    • Spencer, JS, Kim, HJ, Marques, AM, Gonzalez-Juarerro, M, Lima, MCB, Vissa, V, Truman, RW, Gennaro, ML, Cho, SN, Cole, ST, Brennan, PJ. “Comparative analysis of B and T cell epitopes of the Mycobacterium leprae and Mycobacterium tuberculosis culture filtrate protein-10”, Infection and Immunity, 72.6 (2004): 3161-3170.
    • Job, CK, McCormick, GT, Scollard, DM, Truman, RW.“Electron Microscopic Appearance of Lepromatous Footpads of nude mice”, Int J Lepr, 71.3 (2003): 231-238.
    • Pfeiffer, L, and Truman, RW.“Hansen’s Disease in the United States and Louisiana”, Louisiana Morbidity Reports, 14.1 (2003): 1-3.
    • Paige, CF, Scholl, DT, Truman, RW."The prevalence and incidence density of T. cruzi and Mycobacterium leprae infections among wild armadillos in Louisiana", Am J Trop Med Hyg, 67.5 (2002): 528-532.
    • Spencer, JS, Marques, MAM, Lima, MCBS, Junquera-kipnis, AP, Gregory, BC, Truman, RW, Brennan, PJ. "The antigenic specificity of the ESAT-6 Homologue of M. leprae”, Infection and Immunity, 70.2 (2001):1010-3.
    • Truman, RW, and Krahenbuhl, JL. "Viable M. leprae as a research resource" Int J Lepr, 69.1 (2001): 1-12.
    • Truman, RW, and Gillis, TP, "The effect of ultraviolet light radiation on Mycobacterium leprae " Int J Lepr, 68.1 (2000): 11-17.
    • Job, CK, and Truman, RW. “Comparative study of Mitsuda reaction to nude mouse and armadillo lepromin prerarations using nine-banded armadillos”, Int J Lepr, 68.1 (2000): 18-22.
    • Job, CK, and Truman, RW. “Mitsuda negative resistant armadillos and enhanced mitsuda response to live M. Leprae”, Int J Lepr, 67.4 (1999): 475-476.
    • Fine, PEM, and Truman, RW. "Report of the workshop on epidemiology, transmission and vaccines for leprosy", Int J Lepr, 66.4 (1998): 596-599.
    • Job, CK, Truman, RW, et al. "Electron microscopic study of negative mitsuda reaction in nine-banded armadillos", Int J Lepr, 64.3 (1996): 336-339.
    • Scholl, DA, and Truman, RW. "Mathematical simulation model of leprosy transmission in a population of free ranging nine-banded armadillos”, J Computational Medicine, 2 (1996).
    • Scollard, DM, Lathrop, GW, Truman, RW. "Early Nerve Invasion in Armadillos, an Animal Model for Lepromatous Neuopathy", Int J Lepr, 64.2 (1996): 146-152.
    • Truman, RW, Alexander, SA, Hoskins, JD. "Tuberculosis in Cats and Dogs", Perspectives 1.4 (1994): 25-31.
    • Job, CK, Sanchez, RM, Hunt, R, Truman, RW, Hastings, RC. "Armadillos (Dasypus novemcinctus) as a model to test antileprosy vaccines: a preliminary report", Int J Lepr, 61.3 (1993): 394-7.
    • Truman, RW, Sanchez, R.."Armadillos: models for leprosy", Lab Animal 22.1 (1993): 28-32.
    • Job, CK, Drain, V, Truman, RW, Deming, AT, Sanchez, RM, Hastings, RC. "The pathogenesis of leprosy in the nine-banded armadillo and the significance of IgM antibodies to PGL-1", Ind J Lepr, 64.2 (1992): 137-51.
    • Job, CK, Drain, V, Williams, DL, Gillis, TP, Truman, RW, Sanchez, RM, Deming, AJ, Hastings, RC. “Comparison of polymerase chain reaction techniques with other methods for detection of Mycobacterium leprae in tissues of wild nine-banded armadillos”, Lepr Rev, 62 (1991): 362-373.
    • Truman, RW, Kumaresan, JA, McDonough, CM, Job, CK. "Seasonal and spatial trends in the detectability of leprosy in nine-banded armadillos", Epidemiology and Infection, 106 (1991): 549-560.
    • Job, CK, Drain, VD, Truman, RW, Sanchez, RM, Hastings, RC. "Early infection with M. leprae and antibodies to the phenolic glycolipid-1 in the nine-banded armadillo", Int J Lepr 62.2 (1990): 193-201.
    • Truman, RW, Job, CK, Hastings, RC. "Antibodies to the phenolic glycolipid-1 antigen for epidemiological investigations of enzootic leprosy in armadillos ( Dasypus novemcinctus)", Lepr Rev, 61 (1990): 19.
    • Stalkneckt, DW, Truman, RW, Hugh-Jones, ME, Job, CK. "Surveillance for naturally acquired leprosy in a nine-banded armadillo population", J Wildlife Dis, 23.2 (1987): 308.
    • Truman, RW, Morales, MJ, Shannon, EJ, Hastings, RC. "Evaluation of monitoring PGL-1 antibodies in armadillos experimentally infected with M. leprae", Int J Lepr, 54.4 (1986): 720.
    • Truman, RW, Shannon, EJ, Wolf, A, Hugh-Jones, ME, Hagstad, HV, and Hastings, RC. "Evaluation of the origin of leprosy infections in nine-banded armadillos ( Dasypus novemcinctus)", Am J Trop Med Hyg, 35 (1986): 588.

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